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Publications

Books

  1. Friesen WO, Friesen, JA (2010) NeuroDynamix II. Concepts of Neurophysiology Illustrated by Computer Simulations. New York: Oxford University press, 228 pp
  2.  Friesen WO, Friesen JA (1994) NeuroDynamix. Computer Models for Neurophysiology. New York: Oxford University press, 203 pp

 

Major Computer Software

  1. Friesen WO, Friesen, JA (2009) NeuroDynamix II. Neuronal simulation models with preprogrammed lessons; available on-line without charge at www.neurodynamix.net
  2. Hocker CG, Friesen WO (1997) Rhythm Analysis System (RAS). Software for analyzing rhythmic neurophysiological data (period, impulse frequencies, phase and statistics); freely available by contacting wof@virginia.edu
  3. Friesen WO, Friesen, JA (1994) NeuroDynamix. Neuronal simulation models with preprogrammed lessons

 

Leech Neurobiology Research

  1. Iwasaki T, Chen J, Friesen WO (2014) Biological clockwork underlying adaptive rhythmic movements. PNAS 111:978-983 (Full Text)
  2. Mullins OJ, Friesen WO (2012) The brain matters: Effects of descending signals on motor control. J Neurophysiol. 107:2730-41 (Full Text)
  3. Chen J, Friesen WO, Iwasaki T (2012) Mechanisms underlying rhythmic locomotion: interactions between activation, tension and body curvature waves. J Exp Biol 215:211-219 (Full Text)
  4. Mullins OJ, Brodfuehrer PD, Jusufović S, Hackett JT, Friesen WO (2012) Specialized brain regions and sensory inputs that control locomotion in leeches. J Comp Physiol A 198: 97-108 (Full Text)
  5. Friesen, WO, Mullins OJ, Xiao, R, Hackett, JT (2011) Positive feedback loops sustain repeating bursts in neuronal circuits. J Biol Physics 37:317-334 (Full Text)
  6. Chen J, Tian J, Iwasaki T, Friesen WO (2011) Mechanisms underlying rhythmic locomotion: dynamics of muscle activation. J Exp Biol 214:1955-1964 (Full Text)
  7. Chen J, Friesen WO, Iwasaki T (2011) Mechanisms underlying rhythmic locomotion: body-fluid interaction in undulatory swimming. J Exp Biol 214:561-574 (Full Text)
  8. Mullins OJ, Hackett, JT, Friesen, WO (2011) Local-distributed integration by a novel neuron ensures rapid initiation of animal locomotion. J Neurophysiol 105:130–144 (Full Text))
  9. Tian J, Iwasaki T, Friesen WO (2010) Analysis of impulse adaptation in motoneurons. J Comp Physiol A 196:123-136 (Full Text)
  10. Tian J, Iwasaki T, Friesen WO. (2007) Muscle function in animal movement: Passive mechanical properties of leech muscle. J Comp Physiol 193:1205-1219 (Full Text)
  11. Fan RJ, Friesen WO (2006) Morphological and physiological characterization of stretch receptors in leeches. J Comp Neurol 494:290-302 (Full Text)
  12. Fan RJ, Marin-Burgin, A, French, KA, Friesen WO (2005) A dye mixture (Neurobiotin and Alexa 488) reveals extensive dye-coupling among neurons in leeches; physiology confirms the connections. J Comp Physiol 191:1157-1171(Full Text)
  13. Yu X, Friesen WO (2004) Entrainment of leech swimming activity by the ventral stretch receptor. J Comp Physiol A 190:939-949 (Full Text)
  14. Cang J, Friesen WO (2002) Model for intersegmental coordination of leech swimming: Central and sensory mechanisms. J Neurophysiol 87:2760-2769 (Full Text)
  15. Cang J, Yu X, Friesen WO (2001) Sensory Modification of Leech Swimming: Interactions between Ventral Stretch Receptors and Swim-related Neurons. J Comp Physiol A 187: 569-579 (Full Text)
  16. Friesen WO, Hocker CG. (2001) Functional analyses of the leech swim oscillator. J Neurophysiol 86:824-835 (Full Text)
  17. Hocker CG, Yu X, Friesen WO (2000) Functionally heterogeneous segmental oscillators generate swimming movements in the medicinal leech. J Comp Physiol 186:871-883 (Full Text)
  18. Cang J, Friesen WO (2000) Sensory modification of leech swimming: Rhythmic activity of ventral stretch receptors can change intersegmental phase relationships. J Neurosci 20:7822-7829 (Full Text)
  19. Yu X, Nguyen B, Friesen WO (1999) Sensory Feedback Can Coordinate the Swimming Activity of the Leech. J Neurosci 19:4634-4643 (Full Text)
  20. O'Gara BA, Friesen WO (1995) Termination of leech swimming activity by a previously identified swim trigger neuron. J Comp Physiol 177:627-636 (Full Text)
  21. Mangan PS, Cometa AK, Friesen WO (1994) Modulation of swimming behavior in the medicinal leech. IV. Serotonin-induced alterations of synaptic interactions between neurons of the swim circuit, J Comp Physiol 175:723-736 (Full Text)
  22. Mangan PS, Curran GA, Hurney CA, Friesen WO (1994) Modulation of swimming behavior in the medicinal leech. III. Control of cellular properties in motor neurons by serotonin, J Comp Physiol 175:709-722 (Abstract) (Full Text)
  23. Angstadt JD, Friesen WO (1993) Modulation of swimming behavior in the medicinal leech. I. Effects of serotonin on the electrical properties of swim-gating cell 204. J. Comp Physiol. A 59:223-234 (Abstract)
  24. Angstadt JD, Friesen WO (1993) Modulation of swimming behavior in the medicinal leech. II. Ionic conductances underlying serotonergic modulation of swim-gating cell 204. J. Comp Physiol. A 59:235-248 (Abstract)
  25. Gray RA, Friesen WO (1993) Identification of leech neurons using a resonance technique. Proceedings of the Computation and Neural Systems Meeting, San Francisco (Full Text)
  26. Brodfuehrer PD, Kogelnik AM, Friesen WO, Cohen AH (1993) Effect of the tail ganglion on swimming activity in the leech. Behav Neural Biol 59:162-166 (Abstract)
  27. O'Gara BA, Chae H, Latham LB, Friesen WO (1991) Modification of leech behavior patterns by reserpine-induced amine depletion. J Neurosci 11:96-110 (Full Text)
  28. Angstadt JD, Friesen WO (1991) Synchronized oscillatory activity in leech neurons induced by calcium channel blockers. J Neurophysiol 66:1858-1873 (Full Text)
  29. Friesen WO (1989) Neuronal control of leech swimming movements. I. Inhibitory interactions between motor neurons. J Comp Physiol A 166:195-203 (Abstract)
  30. Friesen WO (1989) Neuronal control of leech swimming movements. II. Motor neuron feedback to oscillator cells 115 and 28. J Comp Physiol A 166:205-215 (Abstract)
  31. Hashemzadeh-Gargari H, Friesen WO (1989) Modulation of swimming activity in the medicinal leech by serotonin and octopamine. Comp Biochem Physiol 94C:295-302 (Abstract)
  32. Pearce RA, Friesen WO (1988) A model for intersegmental coordination in the leech nerve cord. Biol Cybernetics 58:301-311 (Full Text)
  33. Debski EA, Friesen WO (1987) Intracellular stimulation of sensory cells elicits swimming activity in the medical leech. J Comp Physiol A 160:447-457 (Abstract)
  34. Nusbaum MP, Friesen WO, Kristan WB Jr, Pearce RA (1987) Neural mechanisms generating the leech swimming rhythm: Swim-initiator neurons excite the network of swim oscillator neurons. J Comp Physiol A 161:355-366 (Abstract)
  35. Brodfuehrer PD, Friesen WO (1986) Control of leech swimming activity by cephalic ganglia. J Neurobiol 17:697-705 (Full Text)
  36. Brodfuehrer PD, Friesen WO (1986) Initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. I. Output pathways of Tr1 and Tr2. J Comp Physiol 159:485-502 (Abstract)
  37. Brodfuehrer PD, Friesen WO (1986) Initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. II. Role of segmental swim-initiating interneurons. J Comp Physiol A 159:503-510 (Abstract)
  38. Brodfuehrer PD, Friesen WO (1986) Initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. III. Sensory inputs to Tr1 and Tr2. J Comp Physiol A 159:511-519 (Abstract)
  39. Brodfuehrer PD, Friesen WO (1986) From stimulation to undulation: An identified pathway for the control of swimming activity in the leech. Science 234:1002-1004 (Abstract)
  40. Debski EA, Friesen WO (1986) The role of central interneurons in the habituation of swimming activity in the medicinal leech. J Neurophysiol 55:977-994 (Full Text)
  41. Debski EA, Friesen WO (1985) Habituation of swimming activity in the medicinal leech. J Exp Biol 116:169-188 (Abstract)
  42. Friesen W (1985) Neuronal control of leech swimming movements: interactions between cell 60 and previously described oscillator neurons. J Comp Physiol A 156:231-242 (Abstract)
  43. Granzow BL, Friesen WO, Kristan WB Jr (1985) Physiological and morphological analysis of synaptic transmission between leech motor neurons. J Neurosci 5:2035-2050 (Full Text)
  44. Pearce RA, Friesen WO (1985) Intersegmental coordination of the leech swimming rhythm. I. Intrinsic period gradient and coupling strength. J Neurophysiol 54:1444-1459 (Full Text)
  45. Pearce RA, Friesen WO (1985) Intersegmental coordination of the leech swimming rhythm. II. Comparison of long and short chains of ganglia. J Neurophysiol 54:1460-1472 (Full Text)
  46. Brodfuehrer PD, Friesen WO (1984) A sensory system initiating swimming activity in the medical leech. J Exp Biol 108:341-355 (Full Text)
  47. Pearce RA, Friesen WO (1984) Intersegmental coordination of leech swimming: comparison of in situ and isolated nerve cord activity with body wall movement. Brain Res 299:363-366  (Full Text)
  48. Phillips CE, Friesen, WO (1982) Ultrastructure of the water-movement-sensitive sensilla in the medicinal leech. J Neurobiol 13:473-486 (Full Text)
  49. DeRosa YS, Friesen WO (1981) Morphology of leech sensilla: observations with the scanning electron microscope. Biol Bull 160:383-393 (Abstract) (Full Text)
  50. Young SR, Dedwylder RD II, Friesen WO (1981) Responses of the medicinal leech to water waves. J Comp Physiol 144:111-116 (Abstract)
  51. Friesen WO (1981) Physiology of water motion detection in the medicinal leech. J Exp Biol 92:255-275 (Full Text)
  52. Stent GS, Kristan WB Jr, Friesen WO, Ort CA, Poon M, Calabrese RL (1978) Neuronal generation of the leech swimming movement. Science 200:1348-1357  (Full Text)
  53. Poon M, Friesen WO, Stent GS (1978) Neuronal control of swimming in the medicinal leech: V. Connexions between oscillatory interneurons and the motor neurones. J Exp Biol 75:45-63 (Full Text)
  54. Friesen WO, Poon ML, Stent GS (1978) Neuronal control of swimming in the medicinal leech: IV. Identification of a network of oscillatory interneurones. J Exp Biol 75:25-43 (Full Text)
  55. Friesen WO, Poon ML, Stent GS (1976) An oscillatory neural circuit generating a locomotory rhythm. Proc Nat Acad Sci 73:3734-3738 (Full Text)
  56. Friesen WO, Stent GS (1977) Generation of a locomotory rhythm by a neural network with recurrent cyclic inhibition. Biol Cybernetics 28:27-40 (Full Text)

 

Reviews

  1. Mullins OJ, Hackett, JT, Buchanan, JT and Friesen, WO (2011) Neuronal Control of Swimming Undulations: Vertebrate versus Invertebrate. Prog Neurobiol, 93:244–269 (Full Text)
  2. Friesen WO (2010) Neuronal circuits that generate swimming movements in leeches. In: Shepherd G and Grillner S (eds.) Handbook of Brain Microcircuits. New York: Oxford University Press, pp 462-469
  3. Friesen, WO (2010) Reciprocal Inhibition. In Encyclopedia of Psychology and Behavioral Science, 4rd edition, Vol 4, (eds), New York: Wiley & Sons
  4.  Friesen, WO (2009) Central pattern generators: Sensory feedback. In: Squire LR (ed.) Encyclopedia of Neuroscience. Volume 2, pp. 701-709. Oxford: Academic Press
  5. Friesen WO, Kristan WB (2007) Leech locomotion: swimming, crawling, and decisions, Curr Opin Neurobiol 17:1–8 (Full Text)
  6. Kristan WB, Calabrese R, Friesen WO (2005) Neuronal control of leech behavior. Prog in Neurobiol 76:279-327 (Full Text)
  7. Friesen WO, Cang J (2001) Sensory and central mechanisms control of intersegmental coordination. Cur Opin in Neurobiol 11:678-683.(Full Text)
  8. Friesen, WO (2000) Reciprocal Inhibition. In The Corsini Encyclopedia of Psychology and Behavioral Science, 3rd edition, Vol 4, Craighead WE & Nemeroff CB (eds), New York: Wiley & Sons, 1375-1377
  9. Brodfuehrer PD, Debski EA, O'Gara BA, Friesen WO (1995) Neuronal control of swimming. J Neurobiol 27:403-418 (Full Text)
  10. Friesen WO (1994) Reciprocal Inhibition: A Mechanism Underlying Oscillatory Animal Movements. Neurosci and Biobehav Rev 18:547-553 (Full Text)
  11. Friesen WO, Pearce RA (1993) Mechanisms of intersegmental coordination in leech locomotion. Sem Neurosci 5:41-47  (Full Text)
  12. Friesen WO (1989) Hierarchical organization of neuronal circuits that control animal locomotion. In: Erber J, Menzel R, Pflüger H-J, Todt D (eds) Neural Mechanisms of Behavior. Georg Thieme Verlag, New York pp, 105-110
  13. Friesen WO (1989) Neuronal control of leech swimming movements. In: Jacklet JW (ed) Cellular and Neuronal Oscillators. Marcel Dekker, New York pp, 269-316 (Abstract)
  14. Friesen WO, Stent GS (1978) Neural circuits for generating rhythmic movements. Ann Rev Biophys and Bioeng 7:37-61 (Abstract) (Full Text)

 

Modeling, comments, and miscellany

  1. Casiraghi LP, Oda GA, Chiesa JJ, Friesen WO, Golombek DA (2012) Forced desynchronization of activity rhythms in a model of chronic jet lag in mice. J Biol Rhythms. 27:59-69 (Abstract) (Full Text)
  2. Oda GA, Friesen WO (2011) Modeling Two-Oscillator Circadian Systems Entrained by Two Environmental Cycles. PLoS ONE 6(8): e23895. Epub 2011 Aug 19. (Full Text)
  3. Humphrey JAC, Chen J, Iwasaki T, Friesen WO (2010) Corrections to the theory and the optimal line in the swimming diagram of Taylor (1952). J. R. Soc. Interface 7: 1243-1246 (Full Text)
  4. Schwartz MD, Wotus C, Liu T, Friesen WO, Borjigin J, Oda GA, de la Iglesia HO  (2009) Dissociation of circadian and light inhibition of melatonin release through forced desynchronization in the rat. Proc Natl Acad Sci USA, 106:17540-5 (Full Text)
  5. Chen Z, Zheng M, Friesen WO, Iwasaki T (2008) Multivariable harmonic balance analysis of the neuronal oscillator for leech swimming. J Comput Neurosci. 25:583-606 (Full text)
  6. Zheng M, Friesen WO, Iwasaki T (2007) Systems-level modeling of neuronal circuits for leech swimming.  J Comput Neurosci 22:21-38 (Full Text)
  7. Levy WB, Sangrey TD, Friesen WO, Crotty P (2007) Reply to Jurisic and Bezanilla’s Letter to the Editor. J Neurophysiol 96:960
  8. Zheng M, Iwasaki T, Friesen WO (2004) Systems approach to modeling the neuronal CPG for leech swimming. Engineering in Medicine and Biology Society Conference Proceedings 1:703-706 (Full Text)
  9. Zheng M, Iwasaki T, Friesen WO (2004) Systems approach to modeling the neuronal CPG for leech swimming. Conf Proc IEEE Eng Med Biol Soc. 1:703-6 (Full Text)
  10. Sangrey TD, Friesen WO, Levy WB (2004) Analysis of the Optimal Channel Density of the Squid Giant Axon Using a Re-parameterized Hodgkin-Huxley Model. J Neurophysiol 91:2541-50 (Full Text)
  11. Oda GA, Friesen WO (2002) A Model for “Splitting” of Running-Wheel Activity in Hamsters. J Biol Rhythms 17:76-88 (Full Text)
  12. Friesen WO, Fleissner G, Fleissner G (2001) Role of feedback loops in the scorpion circadian system. Neurocomputing 38-40:607-614
  13. Oda GA, Menaker M, Friesen WO (2000) Modeling the dual pacemaker system of the tau mutant hamster. J Biol Rhythms 15:246-264 (Full Text)
  14. Wolpert SX, Friesen WO (2000) On the parametric stability of a central pattern generator Neurocomputing 32:603-608
  15. Wolpert SX, Friesen WO, Laffely A (2000) Silicon model of the Hirudo swim oscillator. IEEE Eng   Med Biol 19 (1):64-75
  16. Friesen, WO, Cheek TR, McGuinness OM, Moreton RB, Berridge MJ (1995) Analysis of calcium fertilization transients in mouse oocytes. In Quantitative Neuroendocrinology, vol 28, Johnson ML and Veldius JD (eds.), New York: Academic Press, 388-423
  17. Friesen WO, Block GD, Hocker CG (1993) Formal approaches to understanding biological oscillators. Annu Rev Physiol 55:661-81 (Full Text)
  18. Friesen WO, Block GD (1984) What is a biological oscillator? Am J Physiol 246:R847-R851 (Full Text)
  19. Block GD, McMahon DG, Wallace S, Friesen, WO (1984) Cellular analysis of the Bulla ocular circadian pacemaker system. J Comp Physiol A 155:365-378 (Abstract)
  20.  Friesen WO (1980) Models, modeling and the leech swimming rhythm. Behavioral and Brain Sciences 3:546
  21. Friesen WO, Wyman RJ (1980) Analysis of Drosophila motor neuron activity patterns with neural analogs. Biol Cybernetics 38:41-50 (Abstract)

 

Papers on lobster cardiac ganglion physiology

  1. Krausz HI, Friesen WO (1977) The analysis of nonlinear synaptic transmission. J Gen Physiol 70:243-265 (Full Text)
  2. Krausz HI, Friesen WO (1975) Identification of discrete input nonlinear systems using Poisson impulse trains. In: Proceedings of the First symposium on testing and identification of nonlinear systems. McCann G, Marmarelis P (eds) Calif Inst Tech, Pasadena, pp 125-146
  3. Friesen WO (1975) Antifacilitation and facilitation in the cardiac ganglion of the spiny lobster Panulirus interruptus. J Comp Physiol 101:207-224 (Full Text)
  4. Friesen WO (1975) Synaptic interactions in the cardiac ganglion of the spiny lobster Panulirus interruptus. J Comp Physiol 101:191-205 (Full Text)
  5. Friesen WO (1975) Physiological anatomy and burst pattern in the cardiac ganglion of the spiny lobster Panulirus interruptus. J Comp Physiol 101:173-189 (Full Text)

 

Papers on cardiovascular physiology

  1. Ayotte B, Friesen WO, Rosenhamer GJ, McIlroy MB (1973) A new method of measuring pulmonary diffusing capacity for oxygen in patients with diffuse lung disease. Am Rev Resp Dis 108:587-592
  2. Friesen WO, Rosenhamer, GJ, McIlroy, MB (1972) Ear oximeter calibration using alveolar PO measurements. Scan J Clin Lab Invest 29:37-43 (Full Text)
  3. Rosenhamer GJ, Friesen, WO, McIlroy MB (1971) A bloodless method for measurement of diffusing capacity of the lungs for oxygen. J Appl Physiol 30:603-610 (Full Text)
  4. Weil JV, Byrne-Quinn E, Sodal IE, Friesen WO, Underhill B, Filley GF, Grover RF (1970) Hypoxic ventilatory drive in normal man. J Clin Invest 49:1061-1072 (Full Text)

 

Technical

  1. Wolpert SX, Friesen WO, Laffely A (2000) Silicon model of the Hirudo swim oscillator. IEEE Eng Med Biol 19 (1):64-75
  2. Friesen WO, Brodfuehrer PD (1984) Identification of neurons in the leech through local ionic manipulations. J Exp Biol 113:455-460 (Full Text)
  3. Mitchell CE, Friesen WO (1981) A neuromime system for neural circuit analysis. Biol. Cybernetics 40:127-137 (Abstract)
  4. Friesen WO, Stent GS (1978) Multichannel audio monitor for detecting electrical signals. Rev Sci Instrum 49:1691-1693 (Full Text)
  5. Friesen WO, McIlroy MB (1970) Rapidly responding oxygen electrode for respiratory gas sampling. J Appl Physiol 29:258-259 (Full Text)