1. Cliff Stains
Near-Infrared Dyes
Near-Infrared Dyes
Our laboratory is developing new NIR dyes for applications in imaging and sensing. These scaffolds are being used to develop reagents for fluorescence-guided surgery, deep tissue imaging, and molecular imaging.
Targeted Drug Delivery
Targeted Drug Delivery
We are developing functional molecules that can sense the altered biochemistry of diseased cells and release cytotoxic compounds. Concurrent production of a NIR dye enables imaging of compound delivery.
Dissecting Cellular Communication
Dissecting Cellular Communication
Our group is designing new methods to control as well as measure the activity of signaling enzymes within living cells. These approaches provide fundamental insights into human disease.

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Meet the Group

Bottom row: Cliff Stains; second row from left to right: Julia McAfee, Haoyu Sun; third row from left to right: Meaghan Roberti, Yuan Fang; fourth row from left to right: Ruwen Yin, Miranda Wood, Camille Owen; top row: Frederik Broendsted, Ben June, Dana Bassford, Harry Shield, Yuchen He, Finn Davis, Benjamin Faulkner.  

Research

We seek to improve human health by developing new probes for disease processes as well as targeted therapeutics:

 

 

Selected Publications

  • Fang, Y.; Good, G.N.; Zhou, X. & Stains, C.I. Phosphinate-Containing Rhodol and Fluorescein Scaffolds for the Development of Bioprobes. Chem. Commun. 55, 5962-5965 (2019). DOI: 10.1039/C9CC02492A.
  • Zhou, X; Fang, Y.; Lesiak, L. & Stains, C.I. A Phosphinate‐Containing Fluorophore Capable of Selectively Inducing Apoptosis in Cancer Cells. ChemBioChem 20, 1712-1716 (2019). DOI: 10.1002/cbic.201800811.
  • Zhou, X.; Lesiak, L.; Lai, R.; Beck, J.R.; Zhao, J.; Elowsky, C.G.; Li, H. & Stains, C.I. Chemoselective Alteration of Fluorophore Scaffolds as a Strategy for the Development of Ratiometric Chemodosimeters. Angew. Chem. Int. Ed. 56, 4197-4200 (2017). DOI: 10.1002/anie.201612628