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Near-Infrared Dyes
Near-Infrared Dyes
Our laboratory is developing new NIR dyes for applications in imaging and sensing. These scaffolds are being used to develop reagents for fluorescence-guided surgery, deep tissue imaging, and molecular imaging.
Targeted Drug Delivery
Targeted Drug Delivery
We are developing functional molecules that can sense the altered biochemistry of diseased cells and release cytotoxic compounds. Concurrent production of a NIR dye enables imaging of compound delivery.
Dissecting Cellular Communication
Dissecting Cellular Communication
Our group is designing new methods to control as well as measure the activity of signaling enzymes within living cells. These approaches provide fundamental insights into human disease.

Meet the Group

From left to right: Frederik Brøndsted, Veronica Hubbs, Haoyu Sun, Julia McAfee, Daniel Sitrin, Meaghan Roberti, Yuchen He, Emily Hyun, Jake Cherkis, Benjamin Faulkner, Gabriella Watson, Harry Shield, Yuan Fang, Finn Davis, Megan Garris, Jeremiah Moore, Miranda Wood, and Cliff Stains.

Research

We seek to improve human health by developing new probes for disease processes as well as targeted therapeutics:

 

 

Selected Publications

  • Fang, Y.; Good, G.N.; Zhou, X. & Stains, C.I. Phosphinate-Containing Rhodol and Fluorescein Scaffolds for the Development of Bioprobes. Chem. Commun. 55, 5962-5965 (2019). DOI: 10.1039/C9CC02492A.
  • Zhou, X; Fang, Y.; Lesiak, L. & Stains, C.I. A Phosphinate‐Containing Fluorophore Capable of Selectively Inducing Apoptosis in Cancer Cells. ChemBioChem 20, 1712-1716 (2019). DOI: 10.1002/cbic.201800811.
  • Zhou, X.; Lesiak, L.; Lai, R.; Beck, J.R.; Zhao, J.; Elowsky, C.G.; Li, H. & Stains, C.I. Chemoselective Alteration of Fluorophore Scaffolds as a Strategy for the Development of Ratiometric Chemodosimeters. Angew. Chem. Int. Ed. 56, 4197-4200 (2017). DOI: 10.1002/anie.201612628