Nearly half of Americans try to lose weight by reducing caloric intake each year; however, most of these attempts fail to sustain weight loss in the long-term. Recently popularized diets based on intermittent fasting (or time restricted eating) represent promising interventions to combat overeating, weight gain and metabolic disorder. Patients who restrict their eating to a 6-8 hour window at the height of their active circadian cycle lose weight, have improved glucose tolerance and increased insulin sensitivity. Additionally, these diet regimens improve circadian health, which in turn positively influence many neurological functions including sleep and cognition. Therefore, delineation of the molecular players involved in circadian entrainment and well-being is necessary to implement a well-informed healthy lifestyle that diminishes diseases exacerbated by modernity. The p75 neurotrophic factor receptor (p75NTR) is required for a range of developmental events as well as several adult homeostatic processes (e.g., injury, synaptic plasticity, metabolic balance). Recently, in collaboration with Deppmann Lab, we established p75NTR as a novel regulator time restricted eating. Currently, we are leveraging this finding to strengthen circadian rhythmicity and promote metabolic health.