High-calorie foods and behavior

We have developed a novel mouse behavioral assay designed to probe caloric nutrient sensing. With this test, we investigate food preference within the energy density range of commercially available standard diets. Animals raised on standard diet perform effectively in this paradigm. However, mice raised on energy enriched diets with a wide range of macronutrient calorie sources perform poorly in this test. Our results demonstrate that long-term consumption of certain sugars and/or fats impairs calorie sensing. We further demonstrated that this effect is reversible with exercise and calorie restriction.