Harrison, D. P.; Iovan, D. A.; Myers, W. H.; Sabat, M.; Wang, S.; Zottig, V. E.; Harman, D. [4 + 2] Cyclocondensation Reactions of Tungsten–Dihydropyridine Complexes and the Generation of Tri- and Tetrasubstituted Piperidines. Journal of the American Chemical Society 2011, 133, 18378-18387.
Abstract
A new method for the preparation of functionalized piperidines is described in which various dihydropyridine (DHP) complexes of {TpW(NO)(PMe3)} that are derived from pyridine–borane undergo [4 + 2] cyclocondensation with enones, enals, nitrosobenzene, and several isocyanates to form [2.2.2] bicyclic species. In several cases the diazabicyclooctene products derived from DHP complexes and isocyanates can be further elaborated into novel syn-2,5-disubstituted and 2,3,6-trisubstituted piperidinamides.
