This study used multi-reporter data to examine personality traits and emotion regulation/coping skills as moderators of associations between different types of anxiety and future occupational outcomes in a community sample of 184 emerging adults followed from ages 17-30. Trait anxiety, anxious arousal, rejection sensitivity, and implicit rejection were examined as predictors of later career-related ambition, work performance, job satisfaction, and career satisfaction. Conscientiousness, grit, emotion regulation (ER) and coping skills were analyzed as potential moderators. Although trait anxiety was the only anxiety variable predictive of occupational outcomes in regression analyses, personality variables and ER skills interacted with multiple types of anxiety to predict occupational outcomes. Findings reflected a pattern in which conscientiousness and ER skills mitigated negative effects of anxiety to predict better career outcomes. Findings suggest that traits such as conscientiousness and ER skills may be particularly helpful in the context of high anxiety to promote positive career development.