Biology
Our research focuses on developmental–genetic mechanisms of pattern formation, long-distance cellular communication, and stem cell biology. Additional efforts address the evolution of gene regulatory networks and cell behaviors underlying the diversification of adult morphology. We primarily use the experimentally tractable zebrafish and its relatives, as well as other teleosts and amphibians. Of particular interest to us are post-embryonic stem cells, glia, and pigment cells that are derived from the embryonic neural crest and function in generating the adult peripheral nervous system and pigment pattern. Additional work investigates patterning and morphogenesis of skin, scales, and other traits. The group uses many approaches including super-resolution time-lapse imaging, single cell transcriptomics, quantitative genetic analysis, as well as targeted (CRISPR/Cas9) mutagenesis, transgenesis and forward genetic screens. These efforts are facilitated by lab-dedicated infrastructure including multiple laser confocal microscopes (including multiphoton and super-resolution), Illumina sequencing and single cell transcriptomics platforms, and specialized fish facilities. We have a highly supportive and inclusive group of trainees and staff that values collaboration at all levels. We welcome enquiries from propsective postdoctoral scholars, graduate students and undergraduate researchers. For more information please see our website.